Thermo Fisher Scientific Protein Kinase C iota/lambda/PRKCI Monoclonal Antibody (PRKCI/4912)
Human reactive monoclonal antibody targeting Protein Kinase C iota/lambda (PRKCI/4912). Suitable for IHC and peptide array assays. Unconjugated, purified via Protein A/G, supplied in PBS with BSA and sodium azide. Ideal for studying PKC signaling and a...
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PRKCI/4912 |
| Immunogen | Recombinant fragment (around aa100–300) of human PRKCI protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 PKC isoforms have been identified, differing in structure, localization, and substrate specificity. Conventional PKC members (alpha, beta I, beta II, gamma) are Ca²⁺- and phospholipid-dependent, while PRKCI is calcium-independent and phospholipid-dependent. It is not activated by phorbol esters or diacylglycerol.
PRKCI interacts with the small GTPase RAB2 at vesicle tubular clusters (VTCs), phosphorylating GAPDH and influencing microtubule dynamics in the early secretory pathway. It plays a critical role in BCL-ABL-mediated resistance to apoptosis, protecting leukemia cells against drug-induced apoptosis. A single exon pseudogene is mapped on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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