Thermo Fisher Scientific IL12A Monoclonal Antibody (OTI2A8), TrueMAB
IL12A 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도의 액상 형태로 제공됩니다. 인간 시료에 반응하며 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 23–219 of human IL12A produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin 12A (IL-12A) is a signaling cytokine belonging to the Interleukin-6 protein superfamily. The IL-12A alpha chain precursor is a 35 kDa subunit of the disulfide-linked heterodimeric cytokine IL-12 and exhibits diverse biological functions.
IL-12A acts as a growth factor for activated T and NK cells, enhances NK/lymphokine-activated killer cell lytic activity, and stimulates IFN-γ production by PBMCs. It contributes to T-cell-independent induction of IFN-γ, differentiation of Th1 and Th2 cells, and positive regulation of Stat4 phosphorylation.
The IL-12A signaling pathway in innate immunity involves nitric oxide synthase 2A. Together with EBI3, IL-12A forms the heterodimeric cytokine IL-35, which is produced by T regulatory cells and is essential for their suppressive function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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