Thermo Fisher Scientific NMDAR2B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous (PubMed)

• Publications: 2 available

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The antigen is homologous in mouse and rat.
• Specificity: NMDAR2B.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, a mechanism underlying memory and learning. NMDAR2B plays a role in neuronal development and is implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression correlates with memory impairment. Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity. NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is linked to epileptic encephalopathy and autosomal dominant mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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