Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
NMDAR2B 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 반응성. Western blot 및 IHC에 사용 가능. 장기 보관 시 -20°C에서 안정적이며 신경 발달 및 기억 관련 연구에 적합.
- 카탈로그번호
- OSN00028W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous (PubMed)
- Publications: 2 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human NMDAR2B (GRIN2B) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse and rat.
- Specificity: NMDAR2B.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, a mechanism underlying memory and learning. NMDAR2B plays a role in neuronal development and is implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression correlates with memory impairment. Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity. NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is linked to epileptic encephalopathy and autosomal dominant mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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