Thermo Fisher Scientific Lass4 Polyclonal Antibody
Rabbit polyclonal antibody against human LASS4 protein, validated for WB, IHC(P), and ICC/IF applications. Unconjugated, liquid form with 1 mg/mL concentration. Targets sphingolipid synthesis-related protein involved in ceramide metabolism. For researc...
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Thermo Fisher Scientific Lass4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LASS4, corresponding to a region within N-terminal amino acids. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903008 |
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family (LASS1–LASS6) are involved in sphingolipid synthesis.
LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein that increases the levels of long ceramides such as C22:0 and C24:0.
In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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