Thermo Fisher Scientific IGF2 Polyclonal Antibody
IGF2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(파라핀 절편)에 적합합니다. 인체 시료 반응성이 확인되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 세포 성장 관련 신호전달 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human IGF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792685 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HepG2, HepG2 conditioned medium, IGF2-transfected 293T.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.
IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.
The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.
IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.
IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.
Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.
Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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