Thermo Fisher Scientific RASD2 Monoclonal Antibody (OTI1G1), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein predominantly expressed in the striatal region of the brain. It belongs to the RASD subfamily of Ras-related GTP-binding proteins and plays a role in brain development and function. Mice lacking this gene exhibit increased anxiety and motor coordination deficits.
Rhes was identified as TEM2 through analysis of genes upregulated in tumor endothelium. Tumor endothelial markers are notably upregulated during angiogenesis and neoangiogenesis, processes crucial for solid tumor growth. TEMs localized on the cell surface and conserved across species are of interest for anti-angiogenic therapy development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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