Thermo Fisher Scientific TrkB Polyclonal Antibody
Western blot과 IHC에 적합한 TrkB 폴리클로날 항체로, 인간·마우스·랫트 반응성을 보입니다. 합성 펩타이드 면역원으로 제작되었으며, PBS 완충액에 동결건조 형태로 제공됩니다. 신경계 발달 및 유지 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | — |
| Immunohistochemistry (IHC) | 10–50 µg/mL | — |
| Miscellaneous PubMed (Misc) | — | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TrkB conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C. Avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: TrkB.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family central to the development and maintenance of the mammalian nervous system.
It is the receptor for brain-derived neurotrophic factor (BDNF), and together they regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway, leading to cell differentiation.
Mutations in the TrkB gene have been associated with obesity and mood disorders.
Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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