Thermo Fisher Scientific ADAM10 Recombinant Rabbit Monoclonal Antibody (23GB3920)
ADAM10 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot 및 면역세포염색(ICC/IF)에 적합하며, 높은 특이성과 재현성을 제공합니다. 인간 및 랫트 시료에 반응하며, 액상 형태로 -20°C 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3920 |
| Immunogen | A synthesized peptide derived from ADAM10 (700–748AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to a variety of inflammatory responses and programmed cell death. The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma. TNF-α, Notch, and its ligand Delta are all membrane-bound molecules that are cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (a disintegrin and metalloprotease), was identified to cleave TNF-α, Notch, and Delta. The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, Kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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