Thermo Fisher Scientific PTEN Monoclonal Antibody (17.A)
PTEN 단백질을 인식하는 Mouse IgM 단일클론 항체로, Western blot, IHC, ICC/IF 등 다양한 응용 가능. Human 및 Mouse 시료에 반응하며, 종양 억제 단백질 연구에 적합. 4°C 보관, Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:10–1:100 | View 3 publications |
| Immunohistochemistry (IHC) | - | View 19 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| in situ PLA (PLA) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17.A |
| Immunogen | Recombinant human PTEN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10984606 |
Product Specific Information
MA5-12278 targets PTEN in WB, IHC, and ICC/IF applications and shows reactivity with Human and Mouse samples.
The immunogen used is recombinant human PTEN protein.
Target Information
PTEN is a tumor suppressor frequently mutated in various cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, containing a tensin-like domain and a catalytic domain similar to dual-specificity protein tyrosine phosphatases.
Unlike most tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates, negatively regulating intracellular levels of phosphatidylinositol-3,4,5-trisphosphate and AKT/PKB signaling pathway.
PTEN modulates the AKT-mTOR pathway, influencing neuronal integration, dendritic development, and synapse formation during adult neurogenesis. It also acts as a negative regulator of insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form of PTEN shows higher apoptotic potential, while the cytoplasmic nonubiquitinated form exhibits reduced tumor suppressive ability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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