Thermo Fisher Scientific IRAK1 Polyclonal Antibody
Rabbit polyclonal antibody against human IRAK1. Validated for Western blot applications. Predicted reactivity with mouse, rat, and bovine. Supplied as a liquid at 1 mg/mL. For research use only, not for diagnostic use.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792450 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (90%), Rat (92%), Bovine (89%).
- Positive Control: HepG2, PC-12, Rat-2.
- Centrifuge briefly prior to opening the vial.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP to promote its ubiquitination and degradation, and phosphorylate IRF7 to induce activation and nuclear translocation, leading to transcriptional activation of type I IFN genes and antiviral response.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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