Thermo Fisher Scientific ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ESR2/686)
인간 ER-beta 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능하며, Protein A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 2100-MSM2-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ESR2/686)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESR2/686 |
| Immunogen | C-terminus fragment of recombinant human estrogen receptor beta protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55 kDa, though multiple isoforms ranging from 36–59 kDa have been described. Human ER beta was initially cloned and characterized from testis.
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon binding to estrogen, undergoes conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA.
ERs regulate gene transcription positively or negatively via coactivator or corepressor recruitment. Two forms exist: ER alpha (ESR1) and ER beta (ESR2). ER beta binds estrogens with similar affinity to ER alpha and can inhibit ER alpha activity in reproductive tissues.
ER beta is widely expressed and functions as a tumor suppressor, relevant to diseases such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain disease, and cardiovascular disease risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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