Thermo Fisher Scientific beta-2 Defensin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified: BD-1, BD-2, BD-3, BD-4, BD-5, and BD-6. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants toward immature dendritic cells and memory T cells. Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. They contain a six-cysteine motif forming three intra-molecular disulfide bonds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.