Thermo Fisher Scientific BCL2L1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL

in situ PLA (PLA)

• Tested Dilution: 1:1200

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Target Information

The protein encoded by the BCL-X (BCL2L1) gene belongs to the BCL-2 protein family.
Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
These proteins are located at the outer mitochondrial membrane and regulate VDAC opening, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — all key factors in apoptosis.
Alternative splicing produces multiple transcript variants encoding two isoforms:

• The longer isoform acts as an apoptotic inhibitor.
• The shorter isoform acts as an apoptotic activator.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.