Thermo Fisher Scientific PDGFD Monoclonal Antibody (4H2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
TPQSASIKAL RNANLRRDDL YRRDETIQVK GNGYVQSPRF PNSYPRNLLL TWRLHSQENT RIQLVFDNQF GLEEAENDIC RYDFVEVEDI SETSTIIRGR

Target Information

The platelet-derived growth factor (PDGF) family consists of four members: PDGF-A, PDGF-B, PDGF-C, and PDGF-D (also known as spinal cord-derived growth factor-B or iris-expressed growth factor).
PDGF members form disulfide-bonded dimeric isoforms that are important for growth, survival, and function in various connective tissue cells. Their biological effects are mediated via tyrosine kinase receptors PDGFR-α and PDGFR-β, and PDGF-mediated signaling is crucial for the development of many organ systems.

PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulfide-linked homodimer (PDGF-DD). It induces cellular transformation and promotes tumor growth by accelerating tumor cell proliferation and stimulating tumor neovascularization. PDGF-D may play a role in the development of brain tumors and is potentially involved in the progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells, and various tumor cell lines derived from ovarian, renal, and lung cancers, as well as astrocytomas and medulloblastomas. It is also expressed in the human kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.