Thermo Fisher Scientific ARID1A Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (81%), Bovine (84%).
• Positive Control: 293T, A431, HeLa, A549, HepG2, HepG2 nuclear extract.
• Centrifuge briefly prior to opening the vial.
• Store product as a concentrated solution.

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, required for transcriptional activation of genes normally repressed by chromatin.
It possesses at least two conserved domains important for its function:

1. A DNA-binding domain that specifically binds AT-rich DNA sequences recognized by the SNF/SWI complex at the beta-globin locus.
2. A C-terminus region that stimulates glucocorticoid receptor-dependent transcriptional activation.

The protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through protein-DNA or protein-protein interactions.
Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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