Thermo Fisher Scientific AFAP1L2 Polyclonal Antibody
AFAP1L2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트에서 반응하며, 액상 형태로 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific AFAP1L2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AFAP1L2 (Accession Q8N4X5), corresponding to amino acid residues N67–T117 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849890 |
Product Specific Information
Antibody detects endogenous levels of total AFAP1L2.
Target Information
AFAP1L2 (also known as XB130) is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and multiple phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase.
Suppression of AFAP1L2 via siRNA reduces Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3β, and alters cell cycle progression in human lung epithelial cells, suggesting its role as an adaptor in Src signal transduction and cellular regulation.
AFAP1L2 is highly expressed in thyroid tissue and acts as a substrate of RET/PTC kinase, which is implicated in papillary thyroid cancer. Down-regulation of AFAP1L2 reduces Akt activity, inhibiting cell-cycle progression and cancer cell survival, indicating potential as a therapeutic target in thyroid cancer.
At least four isoforms of AFAP1L2 are known to exist.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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