Thermo Fisher Scientific CXXC4 Polyclonal Antibody
Human CXXC4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, Wnt 신호전달 경로 연구 및 CXXC4 관련 암 연구에 적합. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CXXC4. Recombinant protein control fragment (Product # RP-96727). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640288 |
Product Specific Information
- Immunogen sequence:
GSRTSMHHRN DSQRLGKAGC PPEPSLQMAN TNFLSTLSPE HCRPLAGECM NKLKCGAAEA E - Highest antigen sequence identity:
Mouse - 98%, Rat - 98%
Target Information
CXXC4 is a zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. The interaction between CXXC4 and DVL1 competes with DVL1-AXIN binding, although DVL1 has higher affinity for AXIN. In mouse fibroblasts, CXXC4 suppresses Wnt3a-induced beta-catenin activation and inhibits Wnt3a-dependent TCF4 activation, indicating its role as a negative regulator in the Wnt signaling pathway.
Decreased CXXC4 expression has been associated with kidney cancer metastasis, enhanced cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes related to proliferation, invasion, and survival, suggesting its critical role in tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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