Thermo Fisher Scientific Phospho-FRS2 (Tyr436) Polyclonal Antibody
Phospho-FRS2 (Tyr436) 항체로 인간 및 생쥐 시료에서 인산화된 FRS2 단백질 검출에 적합. Western blot, IHC, ICC/IF에 사용 가능. Rabbit Polyclonal IgG로 PBS buffer에 보관되며 -20°C에서 안정적. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FRS2 (Accession Q8WU20), corresponding to amino acid residues around phosphorylated Tyr436. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903080 |
Product Specific Information
Antibody detects endogenous levels of FRS2 only when phosphorylated at Tyrosine 436.
Target Information
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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