Thermo Fisher Scientific Phospho-GRF-1 (Tyr1105) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

RNA polymerase (pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors. To maintain rapid growth, cells must produce high levels of Pol III transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex consists of five subunits (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63), which are overexpressed in transformed and malignant cells, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may play a key role in malignant cell deregulation.
The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1), and TFIIIB, whose expression is also upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, impairing their ability to bind and inactivate TFIIIB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.