Thermo Fisher Scientific Creatine Kinase MT Polyclonal Antibody
Thermo Fisher Scientific의 Creatine Kinase MT Polyclonal Antibody는 인간 단백질에 반응하는 토끼 IgG 기반 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 고에너지 대사 관련 단백질 탐지에 활용됩니다.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 5–262 of Human Creatine Kinase MT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2546947 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa
- Predicted reactivity: Chicken (91%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mitochondrial creatine kinase (MtCK) transfers high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes—sarcomeric MtCK and ubiquitous MtCK—encoded by separate genes.
MtCK forms dimers and octamers, unlike cytosolic creatine kinase which is exclusively dimeric. Overexpression of ubiquitous MtCK has been observed in malignant cancers with poor prognosis, potentially linked to high energy turnover and reduced apoptosis.
Two genes on chromosome 15 encode identical mitochondrial creatine kinase proteins, showing ~80% homology between sarcomeric and ubiquitous forms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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