Thermo Fisher Scientific IRF3 (Transcription Factor) Monoclonal Antibody (PCRP-IRF3-2F9)
IRF3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Human 시료에 반응합니다. Flow Cytometry와 Peptide Array에 적합하며, 세포 내 IRF3의 발현 연구에 유용합니다. 단백질 A/G로 정제된 액상 항체로 4°C에서 보관합니다.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IRF3 (Transcription Factor) Monoclonal Antibody (PCRP-IRF3-2F9)
Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-IRF3-2F9 |
| Immunogen | Recombinant full-length human IRF3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: HeLa, U87, or Ramos cells
- Cellular Location: Cytoplasm and nucleus. IRF3 shuttles between cytoplasmic and nuclear compartments; interaction with CREBBP prevents export to the cytoplasm, though export is typically predominant. When activated, IRF3 translocates to the nucleus.
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a crucial role in innate immunity against DNA and RNA viruses by regulating transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG) through binding to ISRE elements in their promoters.
IRF3 is inactive in the cytoplasm of uninfected cells. Upon viral infection or stimulation via double-stranded RNA or toll-like receptor pathways, it becomes phosphorylated by IKBKE and TBK1 kinases, leading to dimerization, nuclear localization, and complex formation with CREB binding protein (CBP) to activate IFN and ISG transcription. Mutations in IRF3 can cause acute infection-induced encephalopathy (herpes-specific type 7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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