Thermo Fisher Scientific GOLPH3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GOLPH3. Suitable for immunoprecipitation. Predicted cross-reactivity with rat and mouse. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
Immunoprecipitation (IP)
- Tested Dilution: 15–20 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 25 and 75 of human Golgi phosphoprotein 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
Predicted reactivity by homology: Rat, Mouse.
Target Information
GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin.
GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to an increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF.
Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA-treated cells compared to control cells, indicating that GOLPH3 can enhance signaling through TOR-associated complexes.
These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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