Thermo Fisher Scientific PKC gamma Recombinant Rabbit Monoclonal Antibody (JG69-32)
PKC gamma 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 시료 반응성이 있으며, HEK293 세포에서 발현되었습니다. 단백질 A로 정제된 액상 형태로, 안정적인 신호 검출에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JG69-32 |
| Immunogen | Recombinant protein within Human PKC gamma aa 564–697 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848665 |
Product Specific Information
Positive Control: A549, Rat cerebellum tissue, Mouse cerebellum tissue.
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in structure, tissue distribution, localization, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC family members phosphorylate diverse protein targets and are involved in multiple signaling pathways. PKC gamma is expressed exclusively in the brain and spinal cord, localized to neurons, and plays a role in neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies suggest involvement in neuropathic pain development. Defects are associated with spinocerebellar ataxia-14 (SCA14).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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