Thermo Fisher Scientific TCTN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human TCTN1 (NP_0010760061) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TCTN1,uniProtId:Q2MV58-1,ncbiNodeId:9606,antigenRange:130-310,antigenLength:587,antigenImageFileName:PA5-90130_TCTN1_Q2MV58-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90130_TCTN1_Q2MV58-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805931

Product Specific Information

Immunogen sequence: NFTANPPQRV FELVDQINPS IFCIHITNYK PALSFINPEV PDENNFDTLM KTSDGFTLNA ESYVSFTTKL DIPTAAKYEY GVPLQTSDSF LRFPSSLTSS LCTDNNPAAF LVNQAVKCTR KINLEQCEEI EALSMAFYSS PEILRVPDSR KKVPITVQSI VIQSLNKTLT RREDTDVLQP T; Positive Samples: MCF7, HT-29, 293T, NCI-H460; Cellular Location: Cytoplasm, cilium basal body, cytoskeleton

Target Information

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.