Thermo Fisher Scientific CD11b Monoclonal Antibody (M1/70), FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1–3 µg/mL
• Publications: View 2 publications

Miscellaneous PubMed (Misc)

• Publications: View 9 publications

Product Specifications

Available Formats

• Unconjugated (MA1-10080)
• PE (MA1-10082)
• Request custom conjugation

Product Specific Information

This antibody detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes, and NK-cells. CD11b associates with CD18 to form the Mac-1 integrin complex, which plays an important role in cell–cell interactions.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex, also known as integrin alpha-M beta-2, Mac-1, or CR3 (complement receptor 3), is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK and dendritic cells, and microglia.

CD11b/CD18 functions as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X. These interactions are critical for cell–cell and cell–matrix adhesion. CD11b is expressed on approximately 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is widely used as a microglial marker in nervous tissue. Expression increases during monocyte maturation and varies among tissue macrophages, with peritoneal macrophages showing higher levels than splenic macrophages. CD11b dysfunction has been associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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