Thermo Fisher Scientific TRPA1 Polyclonal Antibody
TRPA1 단백질을 인식하는 Sheep Polyclonal 항체로, WB 및 IHC에 사용 가능. Mouse와 Rat에 반응하며, 합성 펩타이드 항원을 사용해 제작됨. 냉각 반응 및 통증 전달 관련 연구에 적합. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1050–1120 of rat TRPA1 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse.
- Specificity: TRPA1.
Target Information
TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds, playing a role in nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, with protein distribution primarily in sensory neurons. Blocking TRPA1 may serve as a therapeutic target for cold hyperalgesia caused by inflammation or nerve damage.
TRPA1 is also expressed outside the CNS and is dysregulated during oncogenic transformation. The protein structure shares similarity with ankyrin and transmembrane proteins. Its function is not fully defined but is believed to be involved in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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