Thermo Fisher Scientific SHANK2 Monoclonal Antibody (S23b-6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• 1 µg/mL of MA5-27634 was sufficient for detection of Shank2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Detects approximately 160 kDa.
• No cross-reactivity against Shank1 or Shank3.
• Weak mouse detection.

Target Information

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides, and a sterile alpha motif.
Alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain.
Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.