Thermo Fisher Scientific TSPO Polyclonal Antibody
TSPO 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, PBS/glycerol 저장용액 포함. 연구용 전용 제품.
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Thermo Fisher Scientific TSPO Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSPO (Accession P30536), corresponding to amino acid residues A134–E169 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852402 |
Product Specific Information
Antibody detects endogenous levels of total TSPO.
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an essential component of the steroidogenic machinery, mediating cholesterol delivery to the inner mitochondrial membrane upon ligand activation.
PBR consists of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier.
It is conserved across species and widely expressed in peripheral organs, while in the brain it is mainly localized in glial cells.
PFDA inhibits Leydig cell steroidogenesis by destabilizing PBR mRNA, reducing PBR expression, cholesterol transport, and steroid formation.
PRAX-1 (Peripheral Benzodiazepine Receptor-Associated Protein 1) specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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