Thermo Fisher Scientific Catenin, beta (p120) Monoclonal Antibody (CTNNB1, 2099)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 min.

Target Information

Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to link the adhesion complex to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless.
It is expressed in various hair follicle cell types and epithelial tissues. Dysregulation of beta-catenin is implicated in several cancers, including colorectal, ovarian, breast, liver, lung, gastric, prostate, and skin tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that regulate genes like cyclin D and c-myc, promoting cell proliferation and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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