Thermo Fisher Scientific CYP1A2 Monoclonal Antibody (OTI1E12), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
The encoded protein localizes to the endoplasmic reticulum and its expression is induced by polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
Although the enzyme’s endogenous substrate is unknown, it can metabolize certain PAHs into carcinogenic intermediates. Other xenobiotic substrates include caffeine, aflatoxin B1, and acetaminophen.
The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.