Thermo Fisher Scientific PLCG2 Polyclonal Antibody
PLCG2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 고순도(>95%) 항체로 다양한 종(인간, 마우스, 랫트)에 반응. 연구용으로 신호전달 관련 단백질 분석에 활용 가능.
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- PA586893
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human PLC gamma2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2803652 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
Mammalian PLC isozymes include PLCβ1–4, PLCγ1–2, PLCδ1–2, and PLCε.
PLCδ1 acts as a calcium signal amplifier and is activated by atypical GTP-binding proteins. It functions as an effector in oxytocin receptor and α1B-adrenoreceptor signaling.
Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLCδ in Alzheimer’s disease brains suggests its involvement in disease pathology.
PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, potentially serving as a marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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