Thermo Fisher Scientific E-Cadherin Monoclonal Antibody (4A2C7)
인간 E-Cadherin을 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot 및 IHC(paraffin)에서 검증되었습니다. 세포접합 및 막 위치 단백질 검출에 적합합니다. Protein A 정제, PBS 버퍼에 안정화제 포함, 4°C 또는 -20°C 보관.
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Thermo Fisher Scientific E-Cadherin Monoclonal Antibody (4A2C7)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A2C7 |
| Immunogen | A synthetic peptide of human E-Cadherin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Cell junction, membrane
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the calcium-dependent adhesion protein superfamily.
It is a glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene (chromosome 16) are associated with gastric, breast, colorectal, thyroid, and ovarian cancers.
Loss of E-Cadherin function contributes to cancer progression through increased proliferation, invasion, and metastasis.
E-Cadherin mediates bacterial adhesion to mammalian cells via its ectodomain, while its cytoplasmic domain is required for internalization.
Reduction or loss of E-Cadherin expression correlates with tumor invasiveness and metastatic potential.
It plays a central role in maintaining tissue architecture and integrity.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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