Thermo Fisher Scientific BTRC Monoclonal Antibody (OTI1F3), TrueMAB
인간 BTRC 단백질(aa 52-354)에 특이적인 단클론 항체로 Western blot에 적합. TrueMAB 형식의 Mouse IgG1 항체이며, 액상 형태로 0.6 mg/mL 농도. PBS/BSA/glycerol buffer에 보관하며 -20°C에서 안정적 저장 가능.
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Applications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F3 |
| Immunogen | Human fragment corresponding to amino acids 52–354 of human BTRC produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are subunits of the SCF ubiquitin ligase complex (SKP1-cullin-F-box), functioning in phosphorylation-dependent ubiquitination.
F-box proteins are categorized into three classes:
- Fbws containing WD-40 domains
- Fbls with leucine-rich repeats
- Fbxs with various protein-protein interaction modules or no recognizable motifs
The BTRC protein belongs to the Fbws class and contains multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins. BTRC interacts with HIV-1 Vpu, linking CD4 to the proteolytic machinery, and associates with phosphorylated IkappaBalpha and beta-catenin destruction motifs. It functions in transcriptional regulation by activating NF-kappaB and inhibiting beta-catenin pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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