Thermo Fisher Scientific DUT Recombinant Rabbit Monoclonal Antibody (6B7N2)
Human DUT 단백질을 표적으로 하는 재조합 토끼 단클론 항체. Western blot 및 ELISA에 최적화된 고특이성 항체. HEK293 발현 시스템에서 생산되었으며 Protein A로 정제됨. 안정적인 액상 형태로 장기 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6B7N2 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 160–252 of human DUT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
IALPSGCYGR VAPRSGLAAK HFIDVGAGVI DEDYRGNVGV VLFNFGKEKF EVKKGDRIAQ LICERIFYPE IEEVQALDDT ERGSGGFGST GKN
Target Information
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-55434_DUT_P33316-3_Rabbit.svg, MA5-55434_DUT_P33316-3_Rabbit_PDP.jpeg)
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