Thermo Fisher Scientific CYP11A1 Recombinant Rabbit Monoclonal Antibody (6G3S1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6G3S1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CYP11A1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP11A1,uniProtId:P05108-1,ncbiNodeId:9606,antigenRange:40-320,antigenLength:521,antigenImageFileName:MA5-55426_CYP11A1_P05108-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55426_CYP11A1_P05108-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: ISTRSPRPFN EIPSPGDNGW LNLYHFWRET GTHKVHLHHV QNFQKYGPIY REKLGNVESV YVIDPEDVAL LFKSEGPNPE RFLIPPWVAY HQYYQRPIGV LLKKSAAWKK DRVALNQEVM APEATKNFLP LLDAVSRDFV SVLHRRIKKA GSGNYSGDIS DDLFRFAFES ITNVIFGERQ GMLEEVVNPE AQRFIDAIYQ MFHTSVPMLN LPPDLFRLFR TKTWKDHVAA WDVIFSKADI YTQNFYWELR QKGSVHHDYR GILYRLLGDS KMSFEDIKAN V

Target Information

CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.