Thermo Fisher Scientific OVCA2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• View references

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Raji
• Predicted reactivity: Mouse (83%), Rat (84%), Bovine (83%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1, OVCA2, p53, BRCA1, HER2/neu, and others.
OVCA1 and OVCA2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers.
OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast, and other tumor types.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.