Thermo Fisher Scientific Smad1 Monoclonal Antibody (2D9)
Smad1 단백질을 인식하는 토끼 단클론 항체로 Western blot, IHC, ICC에 적합합니다. 비결합형 액상 형태로 제공되며, 1 mg/mL 농도입니다. 세포 성장 및 발달 관련 BMP 신호전달 연구에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D9 |
| Immunogen | Recombinant human Smad1 protein, around N-terminal 1–200 aa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
Target Information
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila mothers against decapentaplegic (Mad) and the C. elegans gene Sma.
SMAD proteins act as signal transducers and transcriptional modulators that mediate multiple signaling pathways.
Smad1 mediates bone morphogenetic protein (BMP) signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses.
Upon BMP ligand stimulation, Smad1 is phosphorylated and activated by BMP receptor kinases, forming a complex with SMAD4 for transcriptional regulation.
It is targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) and undergoes ubiquitination and proteasome-mediated degradation.
Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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