Thermo Fisher Scientific TMC8 Polyclonal Antibody
TMC8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용했으며, 비결합형 동결건조 형태입니다. 마우스 시료에 반응하며 연구용으로 사용 가능합니다.
- 카탈로그번호
- OST00157W-100UL
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 1t cytoplasmic loop of mouse transmembrane channel-like protein 8 (TMC8, EVER2, EVIN2) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TMC8.
Target Information
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses.
Mutations in two homologous genes, EVER1 and EVER2, cause the majority of EV cases. These proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum.
Cells lacking EVER2 accumulate higher levels of zinc in the nucleolus and nucleus compared to cells with an intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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