
Thermo Fisher Scientific TERT Polyclonal Antibody
TERT 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 적합. 합성 펩타이드 항원 기반으로 높은 특이성 제공. Lyophilized 형태로 보관 용이하며, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 1090–1132 of human TERT conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TERT
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by adding the telomere repeat sequence TTAGGG.
The enzyme includes a protein component with reverse transcriptase activity (encoded by the TERT gene) and an RNA component serving as a template for telomere repeat synthesis.
Telomerase expression is normally repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence.
Deregulation of telomerase may contribute to oncogenesis.
Studies in mouse suggest telomerase also aids chromosomal repair by de novo synthesis of telomere repeats at double-stranded breaks.
Alternative splicing generates different isoforms of TERT, which may regulate telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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