Thermo Fisher Scientific ADAMTS10 Monoclonal Antibody (496708)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunoprecipitation (IP)

25 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

496708

Immunogen

CHO-derived recombinant human ADAMTS10 Phe26-Gly1102 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ADAMTS10,uniProtId:Q9H324-1,ncbiNodeId:9606,antigenRange:26-1102,antigenLength:1103,antigenImageFileName:MA5-24207_ADAMTS10_Q9H324-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24207_ADAMTS10_Q9H324-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2605439

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human ADAMTS1, 3, 4, 5, 12, 13, 15, 16, or L2 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer (1-3). Embryogenesis, morphological growth changes, inflammation, tumor invasion and metastasis involve the breakdown and remodeling of the extracellular matrix. This degradation is due to the family of enzymes known as the matrix metalloproteinases (MMPs), which are related to ADAMTS subtypes. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs (1-3). ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver (1-3). The human ADAMTS10 gene maps to chromosome 19p13.3 (4). The human ADAMTS19 gene maps to chromosome 5q31 (1,5).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.