Thermo Fisher Scientific KIAA1524 Monoclonal Antibody (OTI1C11), TrueMAB
KIAA1524(CIP2A) 단백질을 인식하는 Mouse Monoclonal 항체로 Western blot 및 IHC(P) 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상형 항체. 연구용으로 c-Myc 안정화 및 종양 형성과 관련된 CIP2A 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 635–905 of human KIAA1524 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation.
In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A.
Importantly, CIP2A is overexpressed in two common human malignancies: head and neck squamous cell carcinoma (HNSCC) and colon cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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