Thermo Fisher Scientific Caspr2 Recombinant Rabbit Monoclonal Antibody (ARC2430)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC2430

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1232-1331 of human Caspr2/CNTNAP2 (Q9UHC6) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Caspr2,uniProtId:Q9UHC6-1,ncbiNodeId:9606,antigenRange:1232-1331,antigenLength:1331,antigenImageFileName:MA5-37891_Caspr2_Q9UHC6-1_Rabbit.svg,antigenImageFileNamePDP:MA5-37891_Caspr2_Q9UHC6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897811

Product Specific Information

Positive Samples: Mouse spinal cord, Rat brain

Immunogen sequence: HLDHLDSASA DFPYNPGQGQ AIRNGVNRNS AIIGGVIAVV IFTILCTLVF LIRYMFRHKG TYHTNEAKGA ESAESADAAI MNNDPNFTET IDESKKEWLI

Target Information

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.