Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI3C2), TrueMAB
인간 CRYAB 단백질을 인식하는 단클론 항체로 Western blot, IHC, Flow cytometry, IP 등에 사용 가능. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 고순도 친화 크로마토그래피 정제 제품으로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C2 |
| Immunogen | Full length human recombinant protein of human CRYAB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lens proteins are composed mainly of crystallins (about 95%), which are also found in vertebrate skeletal muscle tissue. In the lens, crystallins help maintain the proper refractive index.
There are three major classes of crystallins in the mammalian lens: alpha, beta, and gamma.
- Alpha-crystallin is the largest and consists of alpha-A and alpha-B subunits, comprising about 40% of total lens protein.
- It functions as a molecular chaperone, preventing aggregation that could lead to cataract formation.
- Phosphorylation of alpha-crystallin may occur in response to cellular stress, contributing to protein stability and maintenance.
- Alpha-B crystallin has been associated with Alexander’s disease due to its accumulation in brain cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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