Thermo Fisher Scientific ULBP1 Monoclonal Antibody (7A5A3)
ULBP1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 정제된 재조합 인간 ULBP1 단편(AA 26–216)을 면역원으로 사용하였으며, Protein G로 정제된 액상 형태입니다. 인간 시료에 반응하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7A5A3 |
| Immunogen | Purified recombinant fragment of human ULBP1 (AA: 26–216) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090957 |
Target Information
ULBP1 is a ligand for the NKG2D receptor, along with ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, leading to cytokine and chemokine production. Binding of ULBP ligands to NKG2D induces calcium mobilization and activation of JAK2, STAT5, ERK, and PI3K/Akt pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16, which blocks its interaction with NKG2D and retains ULBP1 in the ER and cis-Golgi apparatus, preventing its expression on the cell surface. This provides a mechanism for CMV-infected cells to evade immune detection.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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