Thermo Fisher Scientific DTYMK Polyclonal Antibody
Rabbit polyclonal antibody targeting human DTYMK for WB, IHC, and IP applications. High specificity and affinity purified. Essential for studying DNA synthesis and thymidylate kinase activity. Suitable for research use only.
- 판매단위
- pk
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Thermo Fisher Scientific DTYMK Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
- Immunoprecipitation (IP): 1–5 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human DTYMK fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902527 |
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and serves as an intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), a chemotherapeutic agent used for several solid tumors.
The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated by cell cycle and cell growth pathways.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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