Thermo Fisher Scientific Dynamin 1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Dynamin 1 (DNM1). Validated for WB and IP applications. Suitable for studying neuronal endocytosis mechanisms. Purified via antigen affinity chromatography and supplied in liquid form for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human DNM1 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902524 |
Target Information
Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane. Its role in endocytosis was first discovered in studies of the temperature-sensitive paralytic shibire mutation in Drosophila melanogaster.
Three closely related isoforms exist in mammals:
- Dynamin 1: expressed exclusively in neurons
- Dynamin 2: ubiquitously expressed
- Dynamin 3: primarily expressed in testes
Each isoform has multiple splice variants, suggesting distinct intracellular targets or vesicle budding functions. Common structural domains include:
- N-terminal GTPase domain
- Central pleckstrin homology domain
- C-terminal proline-rich region with multiple SH3-binding sites
These SH3 domains target dynamin to clathrin-coated pits. Dynamin interacts with proteins such as the AP2 adaptor complex and amphiphysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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