Thermo Fisher Scientific Dynamin 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane. Its role in endocytosis was first discovered in studies of the temperature-sensitive paralytic shibire mutation in Drosophila melanogaster.
Three closely related isoforms exist in mammals:

• Dynamin 1: expressed exclusively in neurons
• Dynamin 2: ubiquitously expressed
• Dynamin 3: primarily expressed in testes

Each isoform has multiple splice variants, suggesting distinct intracellular targets or vesicle budding functions. Common structural domains include:

• N-terminal GTPase domain
• Central pleckstrin homology domain
• C-terminal proline-rich region with multiple SH3-binding sites

These SH3 domains target dynamin to clathrin-coated pits. Dynamin interacts with proteins such as the AP2 adaptor complex and amphiphysin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.