Thermo Fisher Scientific SHARPIN Monoclonal Antibody (OTI1F4), TrueMAB
인간 SHARPIN 단백질(aa 1-326)을 인식하는 마우스 모노클론 항체. Western blot에 적합하며 NF-κB 및 염증 조절 연구에 활용 가능. TrueMAB 형식으로 고순도 정제, 1 mg/mL 농도의 액상 제품. 연구용 한정.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–326 of human SHARPIN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Component of the LUBAC complex, which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-κB activation and regulation of inflammation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-κB and JNK signaling pathways.
Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation.
LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex.
Together with FAM105B/otulin, the LUBAC complex regulates canonical Wnt signaling during angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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