Thermo Fisher Scientific BIN1 Monoclonal Antibody (3B6F10)
BIN1 단백질을 인식하는 Mouse monoclonal antibody (Clone 3B6F10)로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 최적화되어 있습니다. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함.
- 카탈로그번호
- MA531652
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B6F10 |
| Immunogen | Purified recombinant fragment of human BIN1 (AA: 189–398) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787276 |
Product Specific Information
MA5-31652 has been tested in indirect ELISA.
Target Information
The BIN1 gene encodes several isoforms of a nucleocytoplasmic adaptor protein. One isoform was initially identified as a MYC-interacting protein with tumor suppressor features. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Mouse studies suggest this gene plays an important role in cardiac muscle development. Alternate splicing results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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