Thermo Fisher Scientific CEP290 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

5-7 µg/mL

-

Immunocytochemistry (ICC/IF)

2-3 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-RNSKHLKQQQYRAEN. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CEP290,uniProtId:O15078-1,ncbiNodeId:9606,antigenRange:521-535,antigenLength:2479,antigenImageFileName:PA5-142443_CEP290_O15078-1_Goat.svg,antigenImageFileNamePDP:PA5-142443_CEP290_O15078-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933091

Product Specific Information

Additional Information: Despite similarity of the immunizing peptide with the mouse protein, this antibody does not recognize mouse Cep290.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.