Thermo Fisher Scientific TLR7 Monoclonal Antibody (4G1D4)
TLR7 단백질을 인식하는 mouse monoclonal antibody (clone 4G1D4). Western blot, ICC/IF, Flow cytometry, ELISA에 적합. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G1D4 |
| Immunogen | Purified recombinant fragment of human TLR7 (AA: 420–644) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090766 |
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity. TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is located near TLR8. Activation of TLR7 leads to NF-κB signaling, cytokine secretion, and inflammatory responses through MyD88 and TRAF6 pathways. It recognizes pathogen-associated molecular patterns (PAMPs) essential for immune defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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